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FC026 - Fórum Científico
Área: 9 - Ciências do comportamento / Saúde Coletiva
Apresentação: 11/09 (Sábado) - Horário: 14h00 - 15h30 - Sala: 6
Desigualdades na sobrevida dos cânceres de boca, orofaringe e laringe: um estudo de coorte de base hospitalar
Menezes FS, Peres SV, Antunes JLF, Latorre MRDO, Toporcov TN
Educação Em Saúde - UNIVERSIDADE FEDERAL DE SERGIPE
Conflito de interesse: Não há conflito de interesse
Esse trabalho investigou se o status socioeconômico (SES) influencia na sobrevida dos pacientes diagnosticados com cânceres de orofaringe (CO), cavidade bucal (CB) e laringe (CL) no estado de São Paulo. Trata-se de um estudo de coorte de base hospitalar compreendendo os casos diagnosticados de 2000 a 2018. A sobrevida global (SG) em cinco anos foi analisada pelo estimador não paramétrico produto limite de Kaplan-Meier, o teste log-rank e a regressão de Cox. Adicionalmente, verificou-se a sobrevida relativa padronizada por idade, empregando-se o estimador Pohar Perme e a população-padrão da International Cancer Survival Standard 1. Por fim, investigou-se as diferenças na sobrevida entre os gradientes socioeconômicos entre os períodos de diagnóstico. Nos 37.191 casos investigados, a SG em cinco anos foi de 24%, 32% e 40% nas neoplasias malignas de orofaringe, boca e laringe, respectivamente. Na regressão múltipla de Cox, o maior risco de morrer ocorreu no SES mais vulnerável, isto é, analfabetos e pacientes com o tratamento financiado publicamente, ajustando-se para a faixa etária, sexo, estadiamento clínico e tratamentos (cirurgia, quimioterapia e radioterapia). Durante o período investigado, as disparidades na sobrevida aumentaram em 35% no CO, enquanto houve uma redução de 10% no CB e de 30% no CL.
O potencial das iniquidades é maior nas neoplasias malignas de orofaringe do que de boca e laringe. Portanto, a redução das desigualdades socioeconômicas é essencial para melhorar a sobrevida dos pacientes e proporcionar justiça social no acesso à saúde.
FC027 - Fórum Científico
Área: 9 - Ciências do comportamento / Saúde Coletiva
Apresentação: 11/09 (Sábado) - Horário: 14h00 - 15h30 - Sala: 6
SARS-CoV-2 infection among Brazilian dentists: A seroprevalence study
Ribeiro JAM, Farias SJS, Souza TAC, Stefani CM, Lima AA, Lia EN
Odontologia - UNIVERSIDADE DE BRASÍLIA
Conflito de interesse: Não há conflito de interesse
This study aimed to determine the seroprevalence of SARS-CoV-2 infection among Brazilian dentists and its associated factors. A stratified random sample among dentists from 33 administrative regions of the Federal District (Brazil) was performed. The presence of antibodies was verified by the Onsite COVID-19 IgG/IgM Rapid Test. Participants answered a survey about socio-demographic aspects, exposition to COVID-19 and professional practice. The seroprevalence of SARS-CoV-2 infection among 324 selected dentists was 19.1% (n = 62). There was a statistically significant association between seropositivity and previous confirmed diagnosis of COVID-19 (p < 0.0005), loss of taste or smell (p = 0.01), diagnosis of COVID-19 in household (p < 0.0005) and have treated a patient with fever (p = 0.03). Dentists with a previous confirmed diagnosis of COVID-19 had 29.52 (95% CI 12.740 - 68.405, p < 0,0005) times higher odds to exhibit positive serology results. Dentists with a confirmed diagnosis of COVID-19 in the household had 2.46 (95% CI 1.13 - 5.34, p = 0.02) times higher odds to exhibit positive serology results. Professionals presenting loss of taste or smell in the last 15 days had 5.24 (95% CI 1.14 - 24.09, p = 0,03) times higher odds to exhibit positive serology results, and, for those who have treated patients with fever, there were 2.99 (95% CI 1.03 - 8.70, p = 0,04) times higher odds to exhibit negative serology.
There is an urge of more studies to determine at what rate the seroprevalence of COVID-19 is increasing or not among dentists.
(Apoio: EDITAL COPEI-DPI/DEX N° 01/2020)
FC028 - Fórum Científico
Área: 9 - Ciências do comportamento / Saúde Coletiva
Apresentação: 11/09 (Sábado) - Horário: 14h00 - 15h30 - Sala: 6
Versão brasileira do Positive Oral Health and Well-Being (B-POHW): avaliando a saúde bucal positiva
Perazzo MF, Ortiz FR, Zini A, Büssing A, Vered Y, Martins-Júnior PA, Granville-Garcia AF, Paiva SM
Saúde Coletiva - UNIVERSIDADE FEDERAL DE GOIÁS
Conflito de interesse: Não há conflito de interesse
O presente estudo objetivou adaptar transculturalmente e testar as propriedades psicométricas da versão brasileira do Positive Oral Health and Well-Being (B-POHW). Após a tradução para o português brasileiro, a adaptação transcultural do B-POHW foi pré-testada, seguida de coleta de dados para a testagem das propriedades psicométricas. O ajuste do modelo foi testado em 209 participantes (média de idade: 39,36, +12,26) por meio da Análise Fatorial Confirmatória com indicadores categóricos em modelos bifatorial e de estrutura simples. Medidas externas de validação foram representadas por questionários referentes a dados sociodemográficos, hábitos e percepção sobre a saúde bucal, e bem-estar geral. A experiência de cárie dentária foi diagnosticada clinicamente pelos critérios da Organização Mundial da Saúde (índice CPO-D). Para confiabilidade teste-reteste, o B-POHW foi reaplicado em 53 participantes, quinze dias depois. Os seguintes resultados foram encontrados: a) o modelo bifatorial apresentou o melhor ajuste; b) satisfatória consistência interna (α de Cronbach e ω de McDonald> 0,8); c) forte correlação de Spearman para o Fator Global no teste-reteste (rs = 0,85); d) representação do construto de acordo com a base teórica da saúde bucal positiva.
O B-POHW é psicometricamente adequado para ser usado no contexto brasileiro e as evidências de sua estrutura interna confirmaram sua base teórica para mensurar a saúde bucal positiva. Esses achados avançam nas abordagens holísticas, permitindo avaliar a saúde bucal positiva na prática odontológica no Brasil.
(Apoio: CNPq N° 205043/2018-6 | CAPES N° 001)
FC029 - Fórum Científico
Área: 10 - Implantodontia básica e biomateriais
Apresentação: 11/09 (Sábado) - Horário: 16h00 - 16h30 - Sala: 6
Avaliação da associação de PRF e enxerto xenógeno na reparo ósseo de defeitos criticos em calvárias de ratos tratados com ácido zoledrônico
Carneiro BGDS, SOUSA,VC , Costa ACF, Angelino GB, Vasconcelos RF, Gondim DV, Goes P
Morfologia Óssea - UNIVERSIDADE FEDERAL DO CEARÁ
Conflito de interesse: Não há conflito de interesse
O objetivo desse estudo foi avaliar o efeito da associação de PRF e Bio-Oss (BO) na remodelação óssea de defeitos crítico em calvárias de ratos tratados ácido zoledrônico (AZ). Para isto, 24 ratos Wistar machos, receberam previamente AZ em dose única de 120 µg/kg, via s.c., equivalente ao tratamento de osteoporose humano. Sete dias depois foram submetidos a cirurgia para criação de um defeito crítico (8 mm) na calvária e divididos em grupos (n=6) de acordo com o biomaterial utilizado (AZ - sem enxerto; BO - 0,04 ml de Bio-Oss; PRF - 0,04 ml de PRF; BO+PRF - 0,04 ml de ambos). Os animais do grupo controle (C) (n=6) receberam solução salina e sem uso de enxerto. Adicionalmente foram utilizados 6 animais doadores de sangue para obtenção do PRF alogênico. Na 12ª semana, os animais foram eutanasiados e as calvárias submetidas às análises histológica e histomorfométrica. Os dados foram analisados pelos testes ANOVA e Tukey. Os animais do grupo AZ não mantiveram a anatomia da calota, além de apresentarem redução de 34% de osteoblastos, 79% de osteoclastos, 77% vasos sanguíneos e 35% colágeno total, marcada pela redução de colágeno tipo I quando comparado ao controle (p<0,05).
O tratamento com BO apesar de manter a estrutura dimensional do tecido não foi capaz de reverter os efeitos deletérios do AZ sobre células ósseas e vasos. No entanto, o tratamento com BO e PRF promoveu aumento de 37% de osteoblastos, 72% de osteoclastos, 74% vasos sanguíneos e 39% colágeno total, marcado pelo aumento de colágeno tipo I (p<0,05).
(Apoio: CAPES)
HA001 - Hatton
Área: 2 - Biologia pulpar
Apresentação: 10/09 (Sexta-feira) - Horário: 08h30 - 10h00 - Sala: 7
Chronic systemic pain genes may have a role in the development of Apical Periodontitis
Francio J, Neves GST, Letra A, Carneiro E
Endodontia - PONTIFÍCIA UNIVERSIDADE CATÓLICA DO PARANÁ
Conflito de interesse: Não há conflito de interesse
Chronic pain (CP) has affected 30% of people worldwide. Apical periodontitis (AP) is a chronic inflammatory disease characterized by inflammation and destruction of periradicular tissues that result from an infected root canal system. Pain is often seen as a clinical manifestation of AP for which the pathogenesis and molecular players overlap with other CP conditions. For the selection of candidate genes, PubMed was searched using specific terms. 173 genes from studies investigating different chronic conditions were selected. Publications were screened by title and abstract; in cases where this presented insufficient information, the text of the publication was read. 16 genes were finally selected (BDNF, CAMK4, COMT, CTSG, CRHBP, HTR2A, IFRD1, IL1A, KCNS1, MMP9, RAMP1, SCN9A, SCN11A, TIMP1, TFNA, TRPV1). AP tissue samples (n=42) were collected immediately upon apical endodontic surgery. RNA extraction was performed using Trizol and cDNA was synthesized. Control tissues comprised healthy periodontal ligament tissue samples. mRNA levels of target genes were evaluated using SYBR green chemistry in using RT-qPCR and normalized to GAPDH. Data analysis was performed using the 2−ΔΔCt method. P-values ≤ 0.05 were considered statistically significant.
CAMK4, COMT, MMP9, TIMP1 and TNFA were significantly up-regulated in AP tissues. Our findings suggest that these genes may have an important role in the chronic pain associated with Apical Periodontitis. Identifying genes expressed in AP improves knowledge of the condition and provide insight into new therapies.
HA002 - Hatton
Área: 2 - Terapia endodôntica
Apresentação: 10/09 (Sexta-feira) - Horário: 08h30 - 10h00 - Sala: 7
Development and validation of a self-report instrument for the screening of apical periodontitis
Franciscatto GJ, Réquia EC, Rossi-Fedele G, Gauer G, Gomes MS
PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO GRANDE DO SUL
Conflito de interesse: Não há conflito de interesse
This study aimed to develop and validate a self-report instrument to identify patients with apical periodontitis (SRAP). The content and face validities of a 45-item self-report questionnaire were evaluated and the construct validity was tested in a population of 179 individuals through Factor Analysis for Mixed Data (FAMD) and reliability tests (analysis of internal consistency and test-retest). For accuracy evaluation, the SRAP was completely answered by 182 individuals. Diagnostic findings of apical periodontitis (AP) were obtained from panoramic radiographs analysis. The area under the receiver operator curve (AUROC), accuracy, sensitivity (SS), specificity (SP), positive (PPV) and negative predictive values (NPV), positive (PLR) and negative likelihood ratios (NLR) were calculated. After face and content validation, 38 items remained in the pool. After FAMD, 8 items were retained with a Cronbach's alpha of 0.85. The model included 3 factors that explained 33.05% of variance in data: history of endodontic treatment, oral health self-evaluation and history of oral trauma. The prevalence of AP was 54.3%. The SRAP values for the diagnosis of AP were: AUROC (0.685), accuracy (0.615); SS (0.636); SP (0.590); PPV (0.649); NPV (0.576); PLR (1.207) and NLR (0.615).
The 8-item SRAP presented good indexes of construct validity and reliability, showing a predictive power for AP in up to 65% of cases. The SRAP is a low cost, fast and easy to apply instrument, representing an encouraging tool to be used in large-scale population screenings and public health scenarios.
(Apoio: CAPES N° 001 | Australian Academy of Sciences N° 2018)
HA003 - Hatton
Área: 3 - Controle de infecção / Microbiologia / Imunologia
Apresentação: 10/09 (Sexta-feira) - Horário: 08h30 - 10h00 - Sala: 7
Effects of nano-sized sodium hexametaphosphate and fluoride on dual-species biofilms of Streptococcus mutans and Candida albicans
Sampaio C, Delbem ACB, Fernandes AVP, Hosida TY, Morais LA, Camargo ER, Monteiro DR, Pessan JP
Odontologia Preventiva e Restauradora - UNIVERSIDADE ESTADUAL PAULISTA - ARAÇATUBA
Conflito de interesse: Não há conflito de interesse
This study evaluated the effects of nano-sized sodium hexametaphosphate (HMPnano), combined or not with fluoride (F), on dual-species biofilms of Streptococcus mutans and Candida albicans. Solutions containing micrometric HMP (HMPmicro) or HMPnano were prepared at 0.5 or 1%, combined or not with 1,100 ppm F; 1,100 ppm F and artificial saliva were tested as positive and negative controls, respectively. Dual-species biofilms of S. mutans and C. albicans, grown in microtiter plates, were treated (1 min) with the solutions at 72, 78 and 96 h from the beginning of their formation. Biofilms were analyzed by colony-forming unit counting (CFU), metabolic activity (XTT assay), and production of total biomass (crystal violet assay). Data were submitted to ANOVA or Kruskal Wallis test, followed by Tukey's or Student-Newman-Keuls' tests (p<0.05). HMPnano at 1% + F led to the highest CFU reduction of S. mutans, followed by HMP micro at 1% + F and positive control (similar to each other), and the remaining groups; CFU counts of C. albicans were not affected by any solution assessed. Furthermore, HMPnano at 1% led to significant lower metabolic activity compared to all other groups (except for HMPnano at 1% + F). Also, all test solutions promoted significant reductions in biofilm biomass compared to both positive and negative controls.
It can be concluded that HMPnano promoted higher antibiofilm effects compared with its micrometric counterpart for most of the variables assessed, besides having a synergist action with F on CFU reduction of S. mutans.
(Apoio: CAPES N° 001 | CAPES N° 88881.068437/2014-01 | CNPq N° 123611/2019-9)
HA004 - Hatton
Área: 3 - Controle de infecção / Microbiologia / Imunologia
Apresentação: 10/09 (Sexta-feira) - Horário: 08h30 - 10h00 - Sala: 7
Adrenergic signaling and periodontitis: insights on innate immunity response and P. gingivalis virulence factors in an invertebrate model
Moraes RM, Stossi F, Garcia MT, Barros PP, Ribeiro JL, Anbinder AL
Biociências e Diagnóstico Bucal - INSTITUTO DE CIÊNCIA E TECNOLOGIA / ICT-UNESP-SJC
Conflito de interesse: Não há conflito de interesse
Stress is a risk factor for periodontitis, however, the interrelationship between stress (adrenergic system), innate immune response and virulence of periodontopathogens (e.g., Porphyromonas gingivalis-Pg) is still unclear. The study of stress in humans involves variables that are difficult to control, besides individual variations, the complexity of immune response and microbiota. Invertebrate models are a good alternative, as they have similar innate immune response and enable controlled infections. We investigated the action of adrenergic signaling by comparing norepinephrine-NE (α and β agonist) and isoproterenol-ISO (β agonist) on Galleria mellonella immune response and Pg virulence. Dose and time-responses on toxicity and hemocyte density were measured. Both ligands showed opposite effects 30 minutes post-injection: ISO increased the hemocyte number by stimulating sessile hemocyte detachment from the fat body, and NE decreased it. This phenotype correlated with a protective effect of ISO on larval mortality after Pg injection, while NE enhanced the death rate. ISO and NE had similar effects on melanization. Pg was also cultivated in the presence of ISO or NE and then injected into the larvae, to evaluate the direct effects of the ligands on bacterial virulence. ISO-grown bacteria increased the death rate compared to standard Pg controls, and NE had no significant effect.
There is a complex interrelation among stress receptors, innate immune response and bacterial virulence, and their balance is what determines the infection's ultimate outcome.
(Apoio: FAPs - FAPESP N° 2018/25933-3 | FAPs - FAPESP N° 2017/26461-5 | FAPs - FAPESP N° 2018/21701-0)
HA005 - Hatton
Área: 3 - Fisiologia / Bioquimica / Farmacologia
Apresentação: 10/09 (Sexta-feira) - Horário: 08h30 - 10h00 - Sala: 7
Metabolomic identification of novel salivary biomarkers for diagnostic and monitoring Diabetes
Moura DV, Caixeta DC, Santos P, Martins MM, Goulart LR, Sabino-Silva R
Fisiologia - UNIVERSIDADE FEDERAL DE UBERLÂNDIA
Conflito de interesse: Não há conflito de interesse
The diagnostic and monitoring of glycemia is an invasive and painful in diabetes mellitus (DM).Consequently, the search for non-invasive diagnostic biomarkers is of great interest in DM. The limitation to use saliva in clinical settings can be related to the reduced chemical composition knowledge. Here, a characterization of the salivary metabolome is presented in a diabetic animal model. Fluid chromatography coupled to mass spectrometry with time-of-flight system were employed to spot the metabolites in rats saliva. Fifteen Wistar rats were divided in non-diabetic (ND), diabetic (D) and diabetic 6U-treated of insulin (D6U). DM was induced by an intraperitoneal injection (60 mg/kg) of streptozotocin (STZ). The animals were submitted to 28 days of diabetes, and on the 21st day, the insulin- or placebo-treatment was started (#CEUA 13/16). The glycemia and urinary glucose confirmed the diabetic state. The metabolic salivary profile identified hundreds of novel compounds with potential to discriminate diabetes. Principal Component Analysis and clustering indicates 3 main candidates as novel salivary metabolites for salivary screening of diabetes: N-Arachidonoyl tyrosine, 1-11-Eicosenoyl-Triacylglycerol and Dimethylphosphatidylethanolamine (22:5(7Z/24:1(15Z) HMDB, (ANOVA).
Altogether, this salivary metabolomic analysis indicates novel salivary metabolites candidates to be applied in salivary diagnostic salivary platforms for non-invasive diabetic diagnostic platforms and for the salivary monitoring tool during insulin treatment.
(Apoio: CAPES N° (#23038.014934/2020-59). | FAPEMIG N° (#APQ-02872-16) | INCT-TeraNano N° (465669/2014-0))
HA006 - Hatton
Área: 4 - Odontopediatria
Apresentação: 10/09 (Sexta-feira) - Horário: 10h30 - 12h00 - Sala: 7
Selective Outcome Reporting (SOR) in Pediatric Dentistry restorative treatment Randomized Clinical Trials - A systematic Review
Elagami RA, Tedesco TK, Pannuti CM, Seabra G, Braga MM, Mendes FM, Raggio DP
Odontopediatria e Ortodontia - UNIVERSIDADE DE SÃO PAULO - SÃO PAULO
Conflito de interesse: Não há conflito de interesse
We aimed to evaluate the prevalence of SOR in the randomized clinical trials focusing on restorative treatment in primary molars. We searched for RCTs protocol registries in the ClinicalTrials.gov and WHO platform up to April/2021. We included any study classified as an RCT, with two or more experimental arms that evaluated any restorative treatment on primary teeth. The registries that did not result in any publications were excluded. Our search strategy identified 294 registries and 31 publications were included for data extraction. We have also calculated the median of journals' impact factors. Chi-square test was performed with 5% significance level. Our results found that the prevalence of SOR was identified in 19 papers (61.3%). The most common reason was a discrepancy in the primary outcome timeframe (48.4%). Twenty-six (83.9%) of the trials were registered retrospectively. Also, a discrepancy in sponsorship was identified in 22 (71%) of the trials. SOR was associated with the discrepancy in the follow-up period (p=0.003), with no association with registration timing (p=0.948). The impact factor of the journals ranged from 0.213 - 5.79. We found SOR in 9 (29%) of the six high impact factor journals and 10 (32.3%) of the eight with low impact.
Consequently, we emphasized the importance of transparency in RCT focusing on restorative care in children, including properly prospective registration and declaration of any discrepancy in the final manuscript, helping to avoid spin in science.
(Apoio: CAPES N° 001)